Kazuo Nakamura Selected Research

Atherosclerosis

9/2009	Decreased high-density lipoprotein cholesterol level is an independent correlate of circulating tumor necrosis factor-alpha in a general population.
3/2009	Independent determinants of soluble form of receptor for advanced glycation end products in elderly hypertensive patients.
3/2008	Pigment epithelium-derived factor (PEDF) administration inhibits occlusive thrombus formation in rats: a possible participation of reduced intraplatelet PEDF in thrombosis of acute coronary syndromes.
2/2008	Circulating advanced glycation end products (AGEs) and soluble form of receptor for AGEs (sRAGE) are independent determinants of serum monocyte chemoattractant protein-1 (MCP-1) levels in patients with type 2 diabetes.
1/2008	Role of asymmetric dimethylarginine (ADMA) in diabetic vascular complications.
1/2008	Role of oxidative stress in the development of vascular injury and its therapeutic intervention by nifedipine.
10/2007	Kinetics, role and therapeutic implications of endogenous soluble form of receptor for advanced glycation end products (sRAGE) in diabetes.
5/2007	Elevated circulating oxidized LDL levels in Japanese subjects with the metabolic syndrome.
3/2007	Serum levels of sRAGE, the soluble form of receptor for advanced glycation end products, are associated with inflammatory markers in patients with type 2 diabetes.
10/2006	Pigment epithelium-derived factor (PEDF) blocks the interleukin-6 signaling to C-reactive protein expression in Hep3B cells by suppressing Rac-1 activation.

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Kazuo Nakamura Research Topics

Disease

17	Atherosclerosis 09/2009 - 05/2004
15	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2008 - 08/2004
12	Diabetic Angiopathies (Diabetic Angiopathy) 11/2008 - 02/2005
7	Cardiovascular Diseases (Cardiovascular Disease) 05/2010 - 01/2006
5	Inflammation (Inflammations) 01/2017 - 01/2006
5	Neoplasms (Cancer) 07/2012 - 12/2004
5	Hyperglycemia 01/2008 - 02/2006
5	Hypertension (High Blood Pressure) 01/2008 - 12/2003
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 08/2010 - 06/2006
4	Type 2 Diabetes Mellitus (MODY) 01/2009 - 03/2007
4	Ischemia 01/2009 - 03/2006
4	Reperfusion Injury 11/2007 - 03/2006
3	Insulin Resistance 08/2010 - 08/2007
3	Thrombosis (Thrombus) 04/2010 - 03/2008
3	Infarction (Infarctions) 01/2009 - 03/2006
3	Coronary Artery Disease (Coronary Atherosclerosis) 05/2008 - 01/2006
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2008 - 02/2006
3	Uveitis 09/2007 - 02/2007
3	Stroke (Strokes) 02/2005 - 01/2002
2	Fibrosis (Cirrhosis) 01/2017 - 01/2008
2	Obesity 01/2015 - 10/2013
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/2014 - 07/2012
2	Essential Hypertension 08/2010 - 11/2005
2	Acute Coronary Syndrome 03/2008 - 01/2006
2	Necrosis 02/2008 - 02/2007
2	Vascular System Injuries 01/2008 - 06/2007
2	Eye Diseases (Eye Disease) 01/2007 - 11/2005
2	Hepatocellular Carcinoma (Hepatoma) 10/2006 - 05/2006
1	Fatty Liver 01/2017
1	GM2 Gangliosidoses (GM2 Gangliosidosis) 06/2014
1	Carcinoma (Carcinomatosis) 10/2013
1	Chronic Hepatitis C 02/2013
1	Colonic Neoplasms (Colon Cancer) 01/2012
1	Leukemia 12/2010
1	Psoriasis (Pustulosis Palmaris et Plantaris) 03/2010
1	Critical Illness (Critically Ill) 12/2009
1	Sepsis (Septicemia) 12/2009
1	Atrial Fibrillation 08/2009

Drug/Important Bio-Agent (IBA)

27	pigment epithelium-derived factorIBA 01/2017 - 08/2004
26	Advanced Glycation End ProductsIBA 09/2009 - 02/2005
8	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2009 - 05/2004
7	Receptor for Advanced Glycation End ProductsIBA 09/2009 - 11/2005
7	Angiotensin IIIBA 01/2008 - 06/2005
6	Biomarkers (Surrogate Marker)IBA 09/2009 - 03/2007
5	Proteins (Proteins, Gene)FDA Link 12/2009 - 01/2005
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2008 - 12/2004
5	Telmisartan (Micardis)FDA Link 01/2008 - 11/2005
4	P-SelectinIBA 04/2010 - 03/2006
4	NADPH Oxidases (NAD(P)H oxidase)IBA 03/2008 - 06/2005
4	Retinaldehyde (Retinal)IBA 07/2007 - 01/2005
3	GhrelinIBA 01/2015 - 02/2005
3	Angiotensin II Type 1 Receptor BlockersIBA 01/2008 - 01/2008
3	NitrogenIBA 01/2008 - 12/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2008 - 03/2002
2	Cisplatin (Platino)FDA LinkGeneric 02/2014 - 07/2012
2	Glycoproteins (Glycoprotein)IBA 02/2013 - 04/2010
2	AntigensIBA 01/2012 - 12/2010
2	C-Reactive ProteinIBA 09/2009 - 05/2006
2	Taurine FDA Link 01/2009 - 05/2007
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 05/2008 - 07/2006
2	Superoxides (Superoxide)IBA 03/2008 - 06/2007
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 02/2008 - 06/2007
2	oxidized low density lipoproteinIBA 01/2008 - 05/2007
2	Urea (Carbamide)FDA LinkGeneric 01/2008 - 11/2007
2	Fatty Acid-Binding ProteinsIBA 01/2008 - 11/2007
2	CalciumIBA 01/2008 - 01/2006
2	1,4-dihydropyridine (dihydropyridine)IBA 01/2008 - 01/2006
2	PPAR gammaIBA 01/2008 - 01/2008
2	Nifedipine (Adalat)FDA LinkGeneric 01/2008 - 01/2006
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2008 - 06/2007
2	AntioxidantsIBA 09/2007 - 05/2007
2	DNA (Deoxyribonucleic Acid)IBA 07/2007 - 12/2004
2	CytokinesIBA 01/2006 - 02/2005
2	aniracetamIBA 03/2002 - 01/2002
1	G(M2) Ganglioside (Ganglioside GM2)IBA 06/2014
1	LipofuscinIBA 06/2014
1	octanoic acid (caprylic acid)IBA 10/2013
1	EnzymesIBA 10/2013
1	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 10/2013
1	CryoglobulinsIBA 02/2013
1	Antineoplastic Agents (Antineoplastics)IBA 07/2012
1	MucinsIBA 01/2012
1	EpitopesIBA 12/2010
1	gamma-sitosterol (beta-sitosterol)IBA 05/2010
1	CholesterolIBA 05/2010
1	Angiogenic ProteinsIBA 03/2010
1	Peptides (Polypeptides)IBA 03/2010
1	HMGB1 Protein (HMG1)IBA 12/2009
1	PPAR-gamma AgonistsIBA 09/2009
1	Triglycerides (Triacylglycerol)IBA 09/2009
1	Insulin (Novolin)FDA Link 09/2009
1	AcidsIBA 09/2009
1	Fibrinogen (Factor I)FDA Link 09/2009
1	HDL CholesterolIBA 09/2009
1	CreatinineIBA 09/2009
1	Glucose (Dextrose)FDA LinkGeneric 08/2009
1	CD40 Ligand (CD40L)IBA 04/2009
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2009
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2009

Therapy/Procedure

6	Therapeutics 07/2012 - 01/2006